No. Not in the least. 'Lauren Faust, with the chance to work on My Little Pony, she hoped to prove that "cartoons for girls don't have to be a puddle of smooshy, cutesy-wootsy, goody-two-shoeness"'. Direct quote from wikipedia. Also she said she made it not only for the girls, but also their fathers who would be more likely not that watching it with them. So it'd only make sense that males who aren't fathers would like it. But yes: At some points, you have to remember it's for little girls.
Also, the first two episodes are nowhere near the best, so don't watch them and gtfo.