Hey now Setsuna, hold your horses. I have seen the whole "time skip" thing get brought up here and there, and while I see it happening let's not get too hasty. If a time skip does happen it will most likely be a special episode(s) and it would probably show how all the characters have changed and/or show what happens to Amour. A time skip won't permanently affect the show in it's running like Dragon Ball Z or Naruto Shippuden.
I can't say that I envision a timeskip happening either, at least not anytime soon. Seeing Ash and Serena as a real couple when they get older would be amazing though. If the pairing becomes canon, that's the kind of endgame scenario that I want to see rather than some cliffhanger situation where Serena never reveals her feelings to Ash and they just leave each other with no resolution.