My favorite gun in DAH 2 was the Anal Probe, cause of what 'happened' when it was usedI'd definately get it, but I don't have a 360. I loved the other two games. I've always wanted to use telepathy (big surprise) and Destroy All Humans gives you that. Although 2 didn't let you throw things as hard as 1 did. I saw a preview for 3, and I think there was some kind of handgun that does the same thing as the antimatter ray on the UFO.
Which gun is your favorite? I think the Burrow Beast has got to be the most creative. But the best would be the Meteor Gun, cause it's AWESOME, or either the Disintegrator Ray or Ion Detonator, since they're the most useful.