I'd have to agree with Profesco, when I imagine a world with existing pokemon I think of it as if they'd always been there. So, by examining the Pokemon story itself, the same, or at least similar, technologies and adaptations to preserve the environment and protect pokemon would already be in place. Which somewhat debunks the many posts about fire breathing dragons terrorizing the modern world, as we'd either have policies in place keeping these pokemon at bay, or would be used to the horrific event and it would be just like any other day to us.
But, if the OP wanted to clarify and say: Wouldn't it be great if pokemon just suddenly appeared for no reason in modern day life, with no other changes being made, then it would be disastrous. xD
But I shall not lie, I'd love to have a cuddly pokemon to play with. Hmm.. though most of the pokemon I would consider cuddly others may not (Kabutops, Forretress, Onyx..); but who could say no to a Quagsire with arms spread wide, begging for a bear hug? Those dopey eyes... big oblivious smile... *insert fan boy squee here* <3