Well we do know that Red has a Mega Charizard X in Origins. In the universe of the games, Steven might have referred to him. Which of course means Red might have a Mega Charizard in Sun and Moon....which means we get to beat it up.
Plot Twist: the Pikachu with Ash's head is actually Ash and his Pikachu fused together due to the effects of Gamefreak: Secret Wars. It's literally Ashachu...
I actually do think Ash will have a Mega Charizard. He has that bracelet thing, after all. That said, I would rather it be Megazard Y, just to help mix things up, but if not...let it get beat!
BIGGER PLOT TWIST: GF was drawing on this as influence for Ashachu all along:
http://bulbapedia.bulbagarden.net/wiki/Ashachu
It's always kind of been a "comedy", but not too much. This series it seems to clearly be one (heck, they even outright said it).
I got a comedy feel from the early episode, especially due to all the slapstick. Oh, and Ash had personality (I'm glad they're bringing that back), which lent to the comedy. Seriously, the kid has his first kiss (with an actual human, at least), and be barely reacts at all. It's like he has no emotion at all...oh my God! It all makes sense, his toned down personality, his obliviousness to Serena's advances, the fact that he doesn't age...Ash was replaced by a robot! Ash is a Terminator, confirmed!
But yeah, as has been discussed, the anime cann and game canon are separate, but the two universes occasionally overlap, ala Events like the Shiny Genesect, Cilan's Pansage, etc., and even the appearance of the Spiky Ear Pichu and Aura Sphere Riolu. The two versions of the Pokemon World aren't the same, but the aren't entirely dissimilar, either. Still, there is no Ash in the games, that's for sure.