Dan has some pretty good points.
Just look at Star Wars and what they were able to do. If they could make those aliens, they can certainly make Pokémon look real!
And are you people kidding? Using Ash and Co? No way. It would have to be totally new, made up characters just for the movie.
OR It could be about the Pokémon themselves. That would be something new and interesting.
I'm sure they could do very well with a real live movie. With good actors and animation artists it could be done quite well. I'd love to see one especially one that isn't happy-go-lucky. We want PG 13, at least! (Well, I do, anyway.)
~Psychic