Its simple. Say for pikachu. Take two large mice,and breed em. Their genes will make their kids bigger. breed the kids to each other or other huge mice. So it continues, until you've got several whopping big mice. These mice should(Dumb way)
A:Be painted red on their cheeks and yellow on their bodies and rubbed til their static electricity level goes haywire
OR
(Genetic way)
B:Mutating them so blood will rush to their cheeks, making them appear red, altering their fur color with dye or mutation and taking the genes that make electric eels electric..(doh) and implant em. Naturally, a sophisticated organic minute maze would be implanted into their necks, so when the try to squeak, the end up saying "Pikachu"
Charizard is harder.but easy with the right materials. Firstly, we have to have DNA from the earliest birds. This would allow us to make a copy of this reptillian bird. Start cloning several. The ones with less feathers breed, and eventually you have a sort of fling lizard. Genetically mold the beak and give it hands, then change its dna to make it orange. Lastly, make its genes alter so its breath is super hot. Attach 2 gasoline pods on either side of its mouth. When it blows, presto!Fire. Also insert the genetic voice modifier like pikachu.
Ok,this rant is over.
