I do cast my lot with the folks saying rape shouldn't be used as a trashtalk expression or euphemism for videogame defeat, etc., but, like Jb#s is saying, not because I believe it challenges/diminishes the seriousness of rape in serious conversations. If our society doesn't provide the legal and social gravity rape commands, is it because Derek and Jimmy are saying they're gonna "rape" each other in Call of Duty, or are both of these things the results of something bigger and more ingrained? That immature or disrespectful people use the word in a nonliteral/hyperbolic fashion is not a problem (well, not the problem, anyway - it is still a fairly ugly way to speak and act) but a symptom.
The bigger responsibility is, I think, to change the way people think rather than the way they talk. After all, curse words are actually taboo expressions compared to the word rape and they're practically ineradicable, even for otherwise intelligent and sensitive speakers. However, it works the other way around, too: it's possible to change the way people think by first changing the way they talk. That's why I argue alongside Moogles et al.