Lemono said:...and have people interested in reaching the next town.
That's a nifty concept. Perhaps people at the outskirts of town discussing intentions of going to the next city, or maybe even having other people walking through the whole route as opposed to standing there or just pacing back and forth. It'd be cool knocking them out then watching them run to the Pokémon Center, so that if you ever go back there, they might be hanging out there asking for a rematch, even.
Oh, you know what else. In the *real world*, there aren't routes between cities, and sometimes they're even right beside each other with no real seperation aside from municipality signs. Back to back cities might be cool, albeit large and maybe even slightly confusing depending on how they'd go about it.