I don't want to sound rude and no offence if your french but I personally feel that France although a beautiful country is not expansive or has a lot of variety to become a region on its own. Though I do think it can be a central part of what I think is a European based region. I think France Germany UK Italy (hopefully an evil mafia like gang is going to be located there) Spain turkey and Nordic countries are going to be in there. This will give a variety of region areas like a Mediterranean coastal area a Paris like city the market of Istanbul or even the cold tundra areas like Norway.
I'm sorry but i think that's pretty ignorant, France in itself is culturally, geographically and historically diverse enough to be a few regions actually, much in the way there are 4 regions in Japan alone, France, being much larger could also be used for as many, if not more regions.