Claim :
FullMetal Alchemist: Brotherhood
Edward Elric x Alphonse Elric - 345ash-greninja
Possibly the best brotherly relationship ever in any anime, their connection and understanding towards each other, their dynamic is pretty much unparalleled in any other sibling relationship in anime history.
Claim :
FullMetal Alchemist: Brotherhood
Roy Mustang x Riza Hawkeye - 345ash-greninja
Another ship in the series which looks pretty much genuine as their are a lot of indications here in this case as well, their connection and dynamic overall really got invested me in this ship too.