I'm keeping an open mind and I kinda feel good about this upcoming game. Kanto is my least favorite region only because the games have yet to amaze me in some way. I've actually been wanting a "remake" for the first generation more than one for the fourth because I think DPPt shine perfectly on their own as opposed to the bland games Kanto has been restricted to (not counting HGSS here).
I don't see the Go integration being a big deal; some connectivity with added benefits here, the possibility to swipe to chuck a Pokéball there, etc. It would be too bold of a move to have the first Pokémon Switch title be a rehash of Go altogether, so while they want to connect Go and the main series, my guess is that for a first game it will still remain subtle enough.
I'm extremely against Kanto pandering (do not like the idea of Alola forms being exclusive to them, for instance) but I am not against an honest new idea that will maybe bring forth the region's charm. High definition graphics, a new storyline, new characters, new mechanics and new Pokédex will certainly make this game a positive representation of Kanto for those who, like me, have not been smitten by the region yet.