People still get depressed? There's a pill for that.
In truth, I have no answer when it comes to being depressed, because it has been years since I've ever really been "down." That's not to say everyday is bright and full of joy, sunshine, and singing animals, but it has honestly been years where I've been brought down into a "depressed" state. Angry, on the other hand, well, that's another story. That said, whenever I would get depressed, I would just go for a walk. The area is heavily wooded, so the walks were pretty peaceful and scenic, and made quick work of any downed mood.
As for tired, well, I sleep. =P