Possibly, and it'll be Amourshipping that gets the title of the first Ash ship if it happens.
I say "first", because the way things are looking now, I'm kind of expecting Serena to confess to Ash some time in the middle of the saga, with Ash actually reciprocating, but then after trying to make it work, Ash's primary focus of becoming a Pokemon Master eventually wins over, and Ash and Serena call it off on good terms, with the latter going off to try and make something of herself before anything else. They break it off in terms that could imply a possible make-up, Serena leaves just in time for Gen 7 to start, ship chances all around go back to being equal, show ends with no confirmed pairing, everyone can lash out in the aftermath. <3
I don't know how feasible my expectations are, but Serena's crush is being shown too blatantly, too fast for me to think this will simply be something that will be resolved at the final episodes, and there's the matter of it being "XY, anything can happen" and all. Plus, having a confirmed ship for a while opens up new avenues of character development for the two of them, especially if it ends with a mutual breakup. Ash learns there's more to life than training Pokemon, though that shouldn't take a backseat either, Serena learns to be more confident in what she wants to do for herself first, rather than be just "Ash's girlfriend" and little else, it helps out the both of them.